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Dernières publications
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Dylan Moutachi, Janek Hyzewicz, Pauline Roy, Mégane Lemaitre, Damien Bachasson, et al.. Treadmill running and mechanical overloading improved the strength of the plantaris muscle in the dystrophin‐desmin double knockout (DKO) mouse. The Journal of Physiology, In press, ⟨10.1113/JP286425⟩. ⟨hal-04643936⟩
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Medhi Hassani, Dylan Moutachi, Mégane Lemaitre, Alexis Boulinguiez, Denis Furling, et al.. Beneficial effects of resistance training on both mild and severe mouse dystrophic muscle function as a preclinical option for Duchenne muscular dystrophy. PLoS ONE, 2024, 19, ⟨10.1371/journal.pone.0295700⟩. ⟨hal-04501283⟩
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Antonio Atalaia, Dagmar Wandrei, Nawel Lalout, Rachel Thompson, Adrian Tassoni, et al.. EURO-NMD registry: federated FAIR infrastructure, innovative technologies and concepts of a patient-centred registry for rare neuromuscular disorders. Orphanet Journal of Rare Diseases, 2024, 19 (1), pp.66. ⟨10.1186/s13023-024-03059-3⟩. ⟨hal-04460667⟩
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Florent Porquet, Lin Weidong, Kévin Jehasse, Hélène Gazon, Maria Kondili, et al.. Specific DMPK-promoter targeting by CRISPRi reverses myotonic dystrophy type 1-associated defects in patient muscle cells. Molecular Therapy - Nucleic Acids, 2023, 32, pp.857 - 871. ⟨10.1016/j.omtn.2023.05.007⟩. ⟨hal-04287597⟩
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Caroline Le Guiner, T Larcher, A Lafoux, G Toumaniantz, S Webb, et al.. Characterization of the muscular and cardiac diseases of the DMSXL mouse model, a transgenic mouse model for Myotonic Dystrophy type 1. American Society of Gene & Cell Therapy, May 2023, LOS ANGELES, United States. ⟨hal-04096181⟩
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Dylan Moutachi, Mégane Lemaitre, Clément Delacroix, Onnik Agbulut, Denis Furling, et al.. Valproic acid reduces muscle susceptibility to contraction‐induced functional loss but increases weakness in two murine models of Duchenne muscular dystrophy. Clinical and Experimental Pharmacology and Physiology, In press, ⟨10.1111/1440-1681.13804⟩. ⟨hal-04146953⟩
Chiffres clés
145
Publications avec texte intégral
Open Access
53 %
Mots clés
RNA interference
Glucocorticoids
Exercise
Myotonic dystrophy
Therapy
Central nervous system
Brain dysfunction
Transcriptomics
Animals
Intermediate filament
Mice
Transgenic mouse
Myotonic Dystrophy Type 1
Mouse models
Glucocorticoid-receptor
Astrocyte
Myelin
BIOLOGIE MOLECULAIRE
Neuron
Muscle
GSK3
Trinucleotide repeat expansion
Endurance training
DMPK
Cell model
Dystrophie Myotonique
Quantitative microdialysis
Thérapie génique
Cell culture model
RNA splicing
CTG repeats
Brain
Desmin
Mouse model
Trinucleotide Repeat Expansion
MBNL
Gene Therapy
Long read sequencing
AAV
ARN
Acetylcholinesterase knockout mouse
PCR
CTG repeat instability
Diaphragm
Myotonic dystrophy mouse models
Cell penetrating peptide
Autophagy
Dynamin 2
Myotonic Dystrophy type 1
Motoneuron
Heart failure
Hypoxia
Centronuclear myopathy
Gene editing
Genotype phenotype correlation
ACETYLCHOLINESTERASE
Transgenic mouse model
Myotonic dystrophy type 1
PacBio
Glial cells
CRISPR/Cas9
Glutamate
Acetylcholinesterase deficiency
DMSXL mice
CRISPRi
Antisense oligonucleotides
CMS
Alternative splicing
Cultured
CTG repeat contractions
Acute coronary syndrome
Dystrophin
Male
Dystrophie myotonique
Heart
Duchenne muscular dystrophy
Skeletal muscle
Oligodendrocytes
GABA
Aging
KNOCKOUT MICE
Cells
Exercice
CONGENITAL MYATHENIC SYNDROME
Expression
Maximal force
Gene therapy
Antisense oligonucleotide
DM1
RNA biology
Astrocytes
Myostatin
Oligodendrocyte
Cytoskeleton
Dilated cardiomyopathy
Humans
Myotonic Dystrophy
Muscular dystrophy
Cardiac muscle
Fibrosis