Nuclear receptors and endocrine disruption in marine invertebrates: a case study with the Mediterranean mussel Mytilus galloprovincialis - Faculté des Sciences de Sorbonne Université
Article Dans Une Revue Philosophical Transactions of the Royal Society B: Biological Sciences Année : 2024

Nuclear receptors and endocrine disruption in marine invertebrates: a case study with the Mediterranean mussel Mytilus galloprovincialis

Résumé

Endocrine-disrupting chemicals (EDCs) represent a global threat to human health and the environment. In vertebrates, lipophilic EDCs primarily act by mimicking endogenous hormones, thus interfering with the transcriptional activity of nuclear receptors (NRs). The demonstration of the direct translation of these mechanisms into perturbation of NR-mediated physiological functions in invertebrates, however, has rarely proven successful, as the modes of action of EDCs in vertebrates and invertebrates seem to be distinct. In the present work, we investigated the members of the NR superfamily in a bivalve mollusk, the Mediterranean mussel Mytilus galloprovincialis . In addition to annotating the M. galloprovincialis NR complement, we assessed the potential developmental functions and susceptibility to EDC challenge during early development by gene expression analyses . Our results indicate that a majority of mussel NRs are dynamically expressed during early development, including receptors characterized by a potential susceptibility to EDCs. This study thus indicates that NRs are major regulators of early mussel development and that NR-mediated endocrine disruption in the mussel could be occurring at a larger scale and at earlier stages of the life cycle than previously anticipated. Altogether, these findings will have significant repercussions for our understanding of the stability of natural mussel populations. This article is part of the theme issue ‘Endocrine responses to environmental variation: conceptual approaches and recent developments’.
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hal-04445853 , version 1 (18-09-2024)

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Angelica Miglioli, Elza Fonseca, Lydia Besnardeau, Laura Canesi, Michael Schubert, et al.. Nuclear receptors and endocrine disruption in marine invertebrates: a case study with the Mediterranean mussel Mytilus galloprovincialis. Philosophical Transactions of the Royal Society B: Biological Sciences, 2024, Endocrine responses to environmental variation: conceptual approaches and recent developments, 379 (1898), ⟨10.1098/rstb.2022.0500⟩. ⟨hal-04445853⟩
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